When you take that first puff or eat an edible, you might wonder, “How exactly does weed get me high?” It’s all down to some pretty cool science that happens in your body. Cannabis has some unique effects on your brain and perception. Let’s break down how it works, what makes each experience unique, and why you feel the way you do.
The Science Behind THC and the Endocannabinoid System
What is THC and how does it work?
THC (tetrahydrocannabinol) is the main psychoactive compound in cannabis. It’s the stuff that gives you the “high.” When you consume weed, THC gets into your bloodstream and eventually makes its way to your brain. Think of it like a key fitting into a lock. Your brain has specific receptors called CB1 receptors, and THC binds to these, triggering a bunch of effects that make you feel high. You might get giggly, hungry, relaxed, or even a bit spaced out. That’s all thanks to THC making itself right at home in your brain.
The endocannabinoid system and its role in the body
You’ve got this thing inside you called the endocannabinoid system (ECS). It’s like your body’s master regulator, helping maintain balance in things like mood, appetite, sleep, and pain. The ECS has its own natural cannabinoids, which work with the CB1 and CB2 receptors in your body. THC mimics these natural cannabinoids, binding to the receptors and causing changes in how your body and mind function. It’s like THC hijacks your ECS, which is why you feel different after consuming cannabis.
How THC interacts with cannabinoid receptors
When THC binds to CB1 receptors in your brain, it messes with how signals are sent between nerve cells. This interaction is why you experience that classic high – the change in sensory perception, altered mood, and sometimes even a psychedelic boost in creativity. Meanwhile, CB2 receptors, mostly found in the immune system, also play a role in how your body responds to THC, affecting things like inflammation and pain relief.
How Weed Enters and Affects the Body
Methods of consumption and absorption rates
How you consume weed changes how it hits you. Smoking or vaping gives you a fast high because THC goes straight into your lungs and then directly into your bloodstream. You’ll usually feel the effects within minutes. Edibles, on the other hand, take longer to kick in because THC has to go through your digestive system first. That’s why edibles can sneak up on you – they might take 30 minutes to 2 hours to show their full effect.
How inhalation versus ingestion affects the high
Inhaling cannabis gives you a quicker, shorter high, usually peaking within 30 minutes to an hour. When you eat it, THC turns into a compound called 11-hydroxy-THC in your liver, which is more potent and has longer-lasting effects. That’s why edibles can feel much stronger and can last anywhere from 4 to 8 hours, sometimes even longer depending on the dose.
Metabolism of THC in the liver and its impact
Once THC enters your liver, it’s broken down into different metabolites. One of these, 11-hydroxy-THC, crosses the blood-brain barrier more easily than regular THC, which is why it tends to give you a more intense high. This is why edibles can sometimes feel overwhelming if you’re not used to them. Your liver processes THC at its own pace, so patience is key when consuming edibles!
The Stages of Getting High
Onset of effects after consumption
When you smoke or vape cannabis, the effects usually kick in within minutes. You’ll feel the initial buzz, like a warm sensation that spreads throughout your body. With edibles, you’ll notice a slower build-up. The effects start subtly and gradually intensify as the THC is metabolized.
Peak effects and their duration
The peak of your high depends on the method of consumption. Smoking or vaping tends to peak around 30 minutes to an hour, giving you a euphoric and relaxed state. Edibles, however, peak much later – usually around 2 to 4 hours after consumption – and the effects are generally more intense and longer-lasting.
The come-down phase and after-effects
As your body starts to process and break down THC, the effects will gradually taper off. This phase can include feelings of relaxation or sleepiness, sometimes known as the “couch lock” if you’ve consumed a strong strain. After the high, you might feel a bit groggy or tired, kind of like a weed hangover, especially if you overindulged.
Why Different Strains Affect You Differently
The role of THC and CBD ratios
Not all strains are created equal! Some have higher THC content, making them more potent and giving you a stronger high. Others have a balanced ratio of THC and CBD (cannabidiol), which can mellow out the intensity of the high. CBD interacts with your body’s receptors differently, often reducing anxiety and providing a more balanced experience.
Terpenes and their influence on the high
Terpenes are aromatic compounds found in cannabis that give each strain its unique smell and flavor. But they do more than just smell good – they also affect how the THC impacts you. For example, strains high in limonene (a citrusy terpene) might give you an energetic, uplifting high, while strains rich in myrcene (a musky terpene) tend to have more relaxing effects.
The impact of individual tolerance and body chemistry
Your personal tolerance plays a huge role in how cannabis affects you. If you’re new to smoking, even a small amount can hit you hard. If you’re a regular user, you might need a bit more to feel the same effects. Everyone’s body chemistry is different, so what works for one person might not work the same for you.
Factors That Influence the Intensity of the High
Dosage and potency of the strain
The amount of THC you consume directly impacts the intensity of your high. Stronger strains with higher THC levels will naturally produce a more intense effect. Always start with a low dose, especially if you’re trying a new strain or method of consumption.
Frequency of cannabis use
If you use cannabis frequently, you’ll build up a tolerance over time. This means you might not get as high as someone who only uses it occasionally. Taking breaks (sometimes called a “tolerance break”) can help reset your tolerance levels.
Set and setting: Mental state and environment
Your mindset and environment can significantly affect your high. If you’re feeling stressed or anxious, your high might amplify those feelings. Being in a comfortable, safe place with good vibes can help you have a more positive experience.
Potential Side Effects of Getting High
Common physical side effects (dry mouth, red eyes)
THC can cause some physical effects like dry mouth (commonly known as “cottonmouth”) and red eyes. It’s normal and usually not something to worry about. Keep some water handy, and eye drops can help if you’re heading out in public.
Psychological effects (paranoia, anxiety)
Some people might experience increased anxiety or paranoia, especially if they consume too much. This usually happens when THC overwhelms your endocannabinoid system. If this happens, try to stay calm, breathe, and remind yourself that the feeling will pass.
What to do if you experience an unpleasant high
If you find yourself too high, don’t panic! Find a quiet, comfortable spot to relax. Drink some water, eat a snack, and take deep breaths. CBD oil can help counteract THC’s effects, so if you have some handy, try using a little.
How Long Does a High Last?
Factors that affect the duration of the high
The length of your high depends on how you consumed cannabis, the potency of the strain, your tolerance, and even your metabolism. Smoking or vaping usually lasts 1 to 3 hours, while edibles can stick around for 6 to 8 hours or more.
The difference between smoking and edibles
Smoking offers a shorter, more intense high, while edibles provide a longer-lasting, sometimes stronger experience. This is due to how THC is processed in your body. Remember, edibles take longer to kick in, so don’t rush to take more if you’re not feeling it right away.
How to speed up the process of coming down
If you want to come down from a high, drinking water, eating food (especially fatty foods), and getting some fresh air can help. CBD can also help counteract the effects of THC, bringing you back to baseline faster.
Can You Build a Tolerance to Weed?
How the body adapts to regular THC exposure
Your body can develop a tolerance to THC with regular use. This means you might need to consume more to get the same high you once did. Your brain reduces the number of CB1 receptors over time, which is why tolerance builds.
Signs that your tolerance is increasing
If you find yourself needing more cannabis to feel the same effects, that’s a sign your tolerance is creeping up. You might also notice the high doesn’t last as long or isn’t as intense as it used to be.
Tips for managing and resetting tolerance
Taking a tolerance break is the best way to reset. A break of just a few days can make a big difference. When you start back up, go slow and use a lower dose to avoid overwhelming your system.
How does THC make you feel high?
THC binds to receptors in your brain, altering how signals are sent. This affects mood, perception, and bodily sensations, resulting in the “high.” It can make you feel euphoric, relaxed, giggly, or even more aware of your surroundings, depending on the dose and strain.
How long does it take for weed to kick in?
Smoking or vaping typically kicks in within minutes, while edibles can take 30 minutes to 2 hours to start working. This difference is due to the way THC is absorbed and processed in your body.
Why do some people not get high from weed?
Some people may have a naturally high tolerance or differences in their endocannabinoid system. Other factors include the method of consumption, the potency of the cannabis, and personal body chemistry.
Can you get too high?
Yes, you can consume too much THC and feel overwhelmed. Symptoms might include anxiety, paranoia, and dizziness. It’s uncomfortable but not life-threatening, and it will pass with time.
What part of weed makes you high?
THC (tetrahydrocannabinol) is the main compound in cannabis responsible for the psychoactive effects. It interacts with receptors in the brain, leading to changes in mood, perception, and sensations.
